Clinical Study on Rexiao decotion for asthma of heat wheezing type at acute stage

• Main Author: Yu-Hua Zhou
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-11-01
• Series: Journal of Hainan Medical University
• Subjects: bronchial asthma; heat wheezing; rexiao decotion
• Online Access: http://www.hnykdxxb.com/PDF/201911/06.pdf

Objective: To study the safety, efficacy and mechanism of Wang Yulin self-made recipe Rexiao decoction in the treatment of acute bronchial asthma (BA). Methods: 80 patients with acute attack BA were randomly divided into western medicine group (n = 40) and traditional Chinese and western medicine group (n = 40). The control group was treated with routine western medicine: salmeterol was inhaled twice a day, combined with oxygen therapy and inducement therapy. The Chinese and Western medical group was treated with Rexiao decoction in the western medical group. The course of treatment is 15 days. Their syndrome score, blood gas analysis (PaC02, Pa02) and induced sputum IL-5, EOS, IL-1 were observed. 3. Pulmonary function (record of kidney, liver function, blood routine and adverse reactions in PEF% Pred, FEV1% Pred), group). Results: the total effective rate was 85% in western medicine group and 92.5% in traditional Chinese and western medicine group (P < 0.01). After treatment, the score of TCM syndromes in the Chinese and western medicine group was better than that in the western medicine group (P < 0.05). After treatment, the pulmonary function (FEV1% Pred) of the traditional Chinese and western medicine group was better than that of the western medicine group, and the PEF% Pred of the Chinese and western medicine group was better than that of the western medicine group. Analysis of Blood Gas in traditional Chinese and Western Medicine Group after treatment (PaO2) was significantly higher than that in the control group (P< 0.05). There was no significant difference in the improvement of blood gas analysis (PaCO2) between the western medicine group and the traditional Chinese and western medicine group (P > 0.05). The decrease of IL-13,EOS and IL-5 in sputum of traditional Chinese and western medicine group was more than that of western medicine group (P < 0.01). There was no significant difference in liver function (AST, ALT), renal function (Cr, Urea), blood routine (WBC, RBC, PLT) before and after treatment in traditional Chinese and western medicine group (P > 0.05), but no obvious adverse reactions were found. Conclusions: heat Asthma decoction is safe and effective in the treatment of hot asthma syndrome in acute attack. The target and inflammatory factors, eosinophils are likely to decrease, and the effect of airway inflammation and high reaction are decreased.