Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib

Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib

The main adverse effect of tyrosine kinase inhibitors, such as sunitinib, is cardiac contractile dysfunction; however, the molecular mechanisms of this effect remain largely obscure. MicroRNAs (miRNAs) are key regulatory factors in both cardiovascular diseases and the tyrosine kinase pathway. Theref...

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Bibliographic Details
Main Authors: Li Shen, Congxin Li, Hua Zhang, Suhua Qiu, Tian Fu, Yanfang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
sunitinib
contractile dysfunction
miR-146a
PLN
ANK2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00914/full

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