Transcriptomic Impact of IMA-08401, a Novel AHR Agonist Resembling Laquinimod, on Rat Liver

Transcriptomic Impact of IMA-08401, a Novel AHR Agonist Resembling Laquinimod, on Rat Liver

IMA-08401 (C2) is a novel aryl hydrocarbon receptor (AHR) agonist and selective AHR modulator (SAHRM) that is structurally similar to laquinimod (LAQ). Both compounds are converted to the AHR-active metabolite DELAQ (IMA-06201) in vivo. SAHRMs have been proposed as therapeutic options for various au...

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Bibliographic Details
Main Authors: Stephenie D. Prokopec, Raimo Pohjanvirta, Selma Mahiout, Lars Pettersson, Paul C. Boutros
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
AHR
laquinimod
TCDD
immunomodulator
Online Access:http://www.mdpi.com/1422-0067/20/6/1370

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