Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
Abstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize...
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Wiley-VCH
2019-09-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.201900204 |
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doaj-fd45a41c3a814e2fa5d3bd8e67631e5d2021-03-02T00:31:27ZengWiley-VCHChemistryOpen2191-13632019-09-01891183118910.1002/open.201900204Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange ReactionsMégane Valero0Dr. Anurag Mishra1Jennifer Blass2Remo Weck3Dr. Volker Derdau4Sanofi-Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chemistry Industriepark Höchst Frankfurt GermanySanofi-Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chemistry Industriepark Höchst Frankfurt GermanySanofi-Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chemistry Industriepark Höchst Frankfurt GermanySanofi-Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chemistry Industriepark Höchst Frankfurt GermanySanofi-Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chemistry Industriepark Höchst Frankfurt GermanyAbstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.https://doi.org/10.1002/open.201900204hydrogen isotope exchangedeuteriumiridium catalysisC−H functionalizationhomogeneous catalysis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mégane Valero Dr. Anurag Mishra Jennifer Blass Remo Weck Dr. Volker Derdau |
| spellingShingle |
Mégane Valero Dr. Anurag Mishra Jennifer Blass Remo Weck Dr. Volker Derdau Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions ChemistryOpen hydrogen isotope exchange deuterium iridium catalysis C−H functionalization homogeneous catalysis |
| author_facet |
Mégane Valero Dr. Anurag Mishra Jennifer Blass Remo Weck Dr. Volker Derdau |
| author_sort |
Mégane Valero |
| title |
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions |
| title_short |
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions |
| title_full |
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions |
| title_fullStr |
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions |
| title_full_unstemmed |
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions |
| title_sort |
comparison of iridium(i) catalysts in temperature mediated hydrogen isotope exchange reactions |
| publisher |
Wiley-VCH |
| series |
ChemistryOpen |
| issn |
2191-1363 |
| publishDate |
2019-09-01 |
| description |
Abstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules. |
| topic |
hydrogen isotope exchange deuterium iridium catalysis C−H functionalization homogeneous catalysis |
| url |
https://doi.org/10.1002/open.201900204 |
| work_keys_str_mv |
AT meganevalero comparisonofiridiumicatalystsintemperaturemediatedhydrogenisotopeexchangereactions AT dranuragmishra comparisonofiridiumicatalystsintemperaturemediatedhydrogenisotopeexchangereactions AT jenniferblass comparisonofiridiumicatalystsintemperaturemediatedhydrogenisotopeexchangereactions AT remoweck comparisonofiridiumicatalystsintemperaturemediatedhydrogenisotopeexchangereactions AT drvolkerderdau comparisonofiridiumicatalystsintemperaturemediatedhydrogenisotopeexchangereactions |
| _version_ |
1724245396643905536 |