Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

Abstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize...

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Bibliographic Details
Main Authors: Mégane Valero, Dr. Anurag Mishra, Jennifer Blass, Remo Weck, Dr. Volker Derdau
Format: Article
Language:English
Published: Wiley-VCH 2019-09-01
Series:ChemistryOpen
Subjects:
hydrogen isotope exchange
deuterium
iridium catalysis
C−H functionalization
homogeneous catalysis
Online Access:https://doi.org/10.1002/open.201900204
Description
Summary:Abstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.
ISSN:2191-1363

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