P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.

P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.

Our laboratory has previously demonstrated that peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at the blood-brain...

Full description

Bibliographic Details
Main Authors: Lucy Sanchez-Covarrubias, Lauren M Slosky, Brandon J Thompson, Yifeng Zhang, Mei-Li Laracuente, Kristin M DeMarco, Patrick T Ronaldson, Thomas P Davis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3919782?pdf=render

Similar Items

Similar Items