Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient

Introduction: Multinodular and vacuolating neuronal tumor (MVNT) had been initially described as an epilepsy-related brain tumor, but recent studies demonstrated it could be found incidentally in non-epilepsy patients. Case report: A 33-year-old woman with intractable post-encephalitis epilepsy pres...

Full description

Bibliographic Details
Main Authors: Satoshi Kodama, Yuichiro Shirota, Akifumi Hagiwara, Juuri Otsuka, Kazuya Sato, Yusuke Sugiyama, Harushi Mori, Masako Watanabe, Masashi Hamada, Tatsushi Toda
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Clinical Neurophysiology Practice
Online Access:http://www.sciencedirect.com/science/article/pii/S2467981X19300277
id doaj-fd3e35f7252e4966b16998c58ba9d8ad
record_format Article
spelling doaj-fd3e35f7252e4966b16998c58ba9d8ad2020-11-25T01:26:04ZengElsevierClinical Neurophysiology Practice2467-981X2019-01-014164167Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patientSatoshi Kodama0Yuichiro Shirota1Akifumi Hagiwara2Juuri Otsuka3Kazuya Sato4Yusuke Sugiyama5Harushi Mori6Masako Watanabe7Masashi Hamada8Tatsushi Toda9Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Corresponding author.Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanShinjuku Neuro Clinic, 3-21-18 Hyakunincho, Shinjuku-ku, Tokyo 169-0073, JapanDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanIntroduction: Multinodular and vacuolating neuronal tumor (MVNT) had been initially described as an epilepsy-related brain tumor, but recent studies demonstrated it could be found incidentally in non-epilepsy patients. Case report: A 33-year-old woman with intractable post-encephalitis epilepsy presented a cluster of multinodular T2 hyperintensity in the left temporal lobe, which was very similar to the characteristics of MVNT. Long-term video electroencephalogram demonstrated that the habitual seizures were originated from bilateral temporal area and the interictal epileptic discharges were seen multifocally, although the lesions with MVNT appearance were localized in the left temporal lobe. It was presumed that the epilepsy in this patient was due to encephalitis in the past, and the link between the lesions and the epilepsy in this patient seemed weak. Conclusion: Although MVNT had been considered as an epilepsy-related brain tumor, we suggest it is not necessarily preferable to perform surgical resection of MVNT even on patients with epilepsy, unless epileptic foci are highly related to MVNT. Keywords: Post-encephalitis epilepsy, Brain tumor, Long-term video electroencephalogram, Magnetic resonance imaging (MRI)http://www.sciencedirect.com/science/article/pii/S2467981X19300277
collection DOAJ
language English
format Article
sources DOAJ
author Satoshi Kodama
Yuichiro Shirota
Akifumi Hagiwara
Juuri Otsuka
Kazuya Sato
Yusuke Sugiyama
Harushi Mori
Masako Watanabe
Masashi Hamada
Tatsushi Toda
spellingShingle Satoshi Kodama
Yuichiro Shirota
Akifumi Hagiwara
Juuri Otsuka
Kazuya Sato
Yusuke Sugiyama
Harushi Mori
Masako Watanabe
Masashi Hamada
Tatsushi Toda
Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
Clinical Neurophysiology Practice
author_facet Satoshi Kodama
Yuichiro Shirota
Akifumi Hagiwara
Juuri Otsuka
Kazuya Sato
Yusuke Sugiyama
Harushi Mori
Masako Watanabe
Masashi Hamada
Tatsushi Toda
author_sort Satoshi Kodama
title Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
title_short Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
title_full Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
title_fullStr Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
title_full_unstemmed Multinodular and vacuolating neuronal tumor (MVNT): A presumably incidental and asymptomatic case in an intractable epilepsy patient
title_sort multinodular and vacuolating neuronal tumor (mvnt): a presumably incidental and asymptomatic case in an intractable epilepsy patient
publisher Elsevier
series Clinical Neurophysiology Practice
issn 2467-981X
publishDate 2019-01-01
description Introduction: Multinodular and vacuolating neuronal tumor (MVNT) had been initially described as an epilepsy-related brain tumor, but recent studies demonstrated it could be found incidentally in non-epilepsy patients. Case report: A 33-year-old woman with intractable post-encephalitis epilepsy presented a cluster of multinodular T2 hyperintensity in the left temporal lobe, which was very similar to the characteristics of MVNT. Long-term video electroencephalogram demonstrated that the habitual seizures were originated from bilateral temporal area and the interictal epileptic discharges were seen multifocally, although the lesions with MVNT appearance were localized in the left temporal lobe. It was presumed that the epilepsy in this patient was due to encephalitis in the past, and the link between the lesions and the epilepsy in this patient seemed weak. Conclusion: Although MVNT had been considered as an epilepsy-related brain tumor, we suggest it is not necessarily preferable to perform surgical resection of MVNT even on patients with epilepsy, unless epileptic foci are highly related to MVNT. Keywords: Post-encephalitis epilepsy, Brain tumor, Long-term video electroencephalogram, Magnetic resonance imaging (MRI)
url http://www.sciencedirect.com/science/article/pii/S2467981X19300277
work_keys_str_mv AT satoshikodama multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT yuichiroshirota multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT akifumihagiwara multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT juuriotsuka multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT kazuyasato multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT yusukesugiyama multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT harushimori multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT masakowatanabe multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT masashihamada multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
AT tatsushitoda multinodularandvacuolatingneuronaltumormvntapresumablyincidentalandasymptomaticcaseinanintractableepilepsypatient
_version_ 1725111038673682432