PML: Regulation and multifaceted function beyond tumor suppression

PML: Regulation and multifaceted function beyond tumor suppression

Abstract Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML–RARα and RARα–PML fusion proteins. A body of evidence indicated that PML...

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Bibliographic Details
Main Authors: Kuo-Sheng Hsu, Hung-Ying Kao
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cell & Bioscience
Subjects:
PML
Gene expression
Protein modification
Proteolysis
Stem cell and cancer stem cell renewal
Chemotherapy resistance
Online Access:http://link.springer.com/article/10.1186/s13578-018-0204-8

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http://link.springer.com/article/10.1186/s13578-018-0204-8

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