β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice

Abstract Background The cardiac hormones atrial (ANP) and B-type natriuretic peptides (BNP) moderate arterial blood pressure and improve energy metabolism as well as insulin sensitivity via their shared cGMP-producing guanylyl cyclase-A (GC-A) receptor. Obesity is associated with impaired NP/GC-A/cG...

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Bibliographic Details
Main Authors: Sabine Tauscher, Hitoshi Nakagawa, Katharina Völker, Franziska Werner, Lisa Krebes, Tamara Potapenko, Sören Doose, Andreas L. Birkenfeld, Hideo A. Baba, Michaela Kuhn
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Cardiovascular Diabetology
Subjects:
Natriuretic peptides
Guanylyl cyclase-A
Cyclic GMP
β-Cells
Insulin
Obesity
Online Access:http://link.springer.com/article/10.1186/s12933-018-0747-3

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