A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.

Bibliographic Details
Main Authors: Juan P. Castillo, Alexander B. Tong, Sara Tafoya, Paul J. Jardine, Carlos Bustamante
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23725-5
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spelling doaj-fd2702eb7c8e4254a416e2dbc6cb65802021-06-13T11:15:39ZengNature Publishing GroupNature Communications2041-17232021-06-011211810.1038/s41467-021-23725-5A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structuresJuan P. Castillo0Alexander B. Tong1Sara Tafoya2Paul J. Jardine3Carlos Bustamante4Jason L. Choy Laboratory of Single-Molecule Biophysics, University of CaliforniaJason L. Choy Laboratory of Single-Molecule Biophysics, University of CaliforniaJason L. Choy Laboratory of Single-Molecule Biophysics, University of CaliforniaDepartment of Diagnostic and Biological Sciences and Institute for Molecular Virology, University of MinnesotaJason L. Choy Laboratory of Single-Molecule Biophysics, University of CaliforniaRing ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.https://doi.org/10.1038/s41467-021-23725-5
collection DOAJ
language English
format Article
sources DOAJ
author Juan P. Castillo
Alexander B. Tong
Sara Tafoya
Paul J. Jardine
Carlos Bustamante
spellingShingle Juan P. Castillo
Alexander B. Tong
Sara Tafoya
Paul J. Jardine
Carlos Bustamante
A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
Nature Communications
author_facet Juan P. Castillo
Alexander B. Tong
Sara Tafoya
Paul J. Jardine
Carlos Bustamante
author_sort Juan P. Castillo
title A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
title_short A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
title_full A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
title_fullStr A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
title_full_unstemmed A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
title_sort dna packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.
url https://doi.org/10.1038/s41467-021-23725-5
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