A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.

Bibliographic Details
Main Authors: Juan P. Castillo, Alexander B. Tong, Sara Tafoya, Paul J. Jardine, Carlos Bustamante
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23725-5
Description
Summary:Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.
ISSN:2041-1723

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