Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

• Main Authors: S. Gangemi, A. Saija, A. Tomaino, F. Cimino, R. A. Merendino, P. L. Minciullo, S. Briuglia, M. V. Merlino, B. Dallapiccola, B. Ferlazzo, D. C. Salpietro
• Format: Article
• Language: English
• Published: Hindawi Limited 2003-01-01
• Series: Mediators of Inflammation
• Subjects: Chronic mucocutaneous candidiasis; Familiar chronic nail candidiasis; Protein carbonyl groups; Oxidative stress.
• Online Access: http://dx.doi.org/10.1080/09629350310001599693
• ISSN: 0962-9351; 1466-1861

Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several candidacidal mechanisms, including oxygen-dependent killing mechanisms, mediated by a superoxide anion radical myeloperoxidase-H2O2-halide system, and reactive nitrogen intermediates. We analyzed protein carbonyl groups (considered a useful marker of oxidative stress) in the serum of patients belonging to a five-generation Italian family with an isolated form of FCNC.