Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides

Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides

Abstract Background The emergence of resistance to chemotherapy or target therapy, tumor metastasis, and systemic toxicity caused by available anticancer drugs hamper the successful colorectal cancer (CRC) treatment. The rise in epidermal growth factor receptor (EGFR; human epidermal growth factor r...

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Bibliographic Details
Main Authors: Shu-Ting Hong, Huaching Lin, Chen-Shen Wang, Chih-Hsien Chang, Anya Maan-Yuh Lin, James Chih-Hsin Yang, Yu-Li Lo
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Nanobiotechnology
Subjects:
Afatinib
Epidermal growth factor receptor (EGFR)
Nanoparticles
Cell-penetrating peptides
Colorectal cancer
Targeting delivery
Online Access:http://link.springer.com/article/10.1186/s12951-019-0519-6

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http://link.springer.com/article/10.1186/s12951-019-0519-6

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