Clinical application of FISH method in the early diagnostics of superficial bladder cancer

Patients with primary diagnosis of bladder cancer (42 persons) were studied. FISH analysis performed in all patients showed the following results: 39 (93%) patients were FISH positive and 3 (7%) were FISH negative. The molecular cytogenetic criterion for determining the grade of differentiation of T...

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Main Authors:	A. V. Sevankaev, E. F. Lushnikov, O. B. Karyakin, G. F. Mikhailova, N. A. Gorban, S. V. Bashkatov, E. V. Goloub, T. G. Shkavrova, V. V. Tsepenko
Format:	Article
Language:	Russian
Published:	ABV-press 2020-02-01
Series:	Onkourologiâ
Online Access:	https://oncourology.abvpress.ru/oncur/article/view/1044

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spelling	doaj-fd0dcf9dd13a4d1683fadde9d15050d42021-07-29T08:41:45ZrusABV-pressOnkourologiâ 1726-97761996-18122020-02-0144616510.17650/1726-9776-2008-4-4-61-65927Clinical application of FISH method in the early diagnostics of superficial bladder cancerA. V. Sevankaev0E. F. Lushnikov1O. B. Karyakin2G. F. Mikhailova3N. A. Gorban4S. V. Bashkatov5E. V. Goloub6T. G. Shkavrova7V. V. Tsepenko8Medical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesMedical Radiological Research Centre of Russian Academy of Medical SciencesPatients with primary diagnosis of bladder cancer (42 persons) were studied. FISH analysis performed in all patients showed the following results: 39 (93%) patients were FISH positive and 3 (7%) were FISH negative. The molecular cytogenetic criterion for determining the grade of differentiation of Ta and T1 tumors — chromosomal hyperploidy in morphologically abnormal cells, was suggested. All patients demonstrating increased amount (more than 26%) of abnormal cell with hyperploidy of chromosomes 3, 7 and 17 were found to have high grade malignancies.https://oncourology.abvpress.ru/oncur/article/view/1044
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	A. V. Sevankaev E. F. Lushnikov O. B. Karyakin G. F. Mikhailova N. A. Gorban S. V. Bashkatov E. V. Goloub T. G. Shkavrova V. V. Tsepenko
spellingShingle	A. V. Sevankaev E. F. Lushnikov O. B. Karyakin G. F. Mikhailova N. A. Gorban S. V. Bashkatov E. V. Goloub T. G. Shkavrova V. V. Tsepenko Clinical application of FISH method in the early diagnostics of superficial bladder cancer Onkourologiâ
author_facet	A. V. Sevankaev E. F. Lushnikov O. B. Karyakin G. F. Mikhailova N. A. Gorban S. V. Bashkatov E. V. Goloub T. G. Shkavrova V. V. Tsepenko
author_sort	A. V. Sevankaev
title	Clinical application of FISH method in the early diagnostics of superficial bladder cancer
title_short	Clinical application of FISH method in the early diagnostics of superficial bladder cancer
title_full	Clinical application of FISH method in the early diagnostics of superficial bladder cancer
title_fullStr	Clinical application of FISH method in the early diagnostics of superficial bladder cancer
title_full_unstemmed	Clinical application of FISH method in the early diagnostics of superficial bladder cancer
title_sort	clinical application of fish method in the early diagnostics of superficial bladder cancer
publisher	ABV-press
series	Onkourologiâ
issn	1726-9776 1996-1812
publishDate	2020-02-01
description	Patients with primary diagnosis of bladder cancer (42 persons) were studied. FISH analysis performed in all patients showed the following results: 39 (93%) patients were FISH positive and 3 (7%) were FISH negative. The molecular cytogenetic criterion for determining the grade of differentiation of Ta and T1 tumors — chromosomal hyperploidy in morphologically abnormal cells, was suggested. All patients demonstrating increased amount (more than 26%) of abnormal cell with hyperploidy of chromosomes 3, 7 and 17 were found to have high grade malignancies.
url	https://oncourology.abvpress.ru/oncur/article/view/1044
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Clinical application of FISH method in the early diagnostics of superficial bladder cancer

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