Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer

Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer

BackgroundIt is widely accepted that the oxygen level in tumor tissue is significantly lower than the adjacent normal tissue, thus termed hypoxia. Intratumoral hypoxia represents a major driving force in cancer progression, recurrence, metastasis, and decreased survival. Though multiple gene signatu...

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Bibliographic Details
Main Authors: Lina Qi, Jiani Chen, Yanmei Yang, Wangxiong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
HIF-1
hypoxia
KRAS mutation
M2 macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.566430/full

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