Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation

Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation

Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, a...

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Main Authors: Bo Pang, Rijing Liao, Zhijun Tang, Shengjie Guo, Zhuhua Wu, Wen Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23475-4
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spelling doaj-fcfe808743254d1d891ebd54211927772021-05-30T11:13:03ZengNature Publishing GroupNature Communications2041-17232021-05-0112111210.1038/s41467-021-23475-4Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formationBo Pang0Rijing Liao1Zhijun Tang2Shengjie Guo3Zhuhua Wu4Wen Liu5State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of SciencesShanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of SciencesState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of SciencesCaerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, and clarify the process for 2,2’-bipyridine furcation.https://doi.org/10.1038/s41467-021-23475-4
collection DOAJ
language English
format Article
sources DOAJ
author Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
spellingShingle Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
Nature Communications
author_facet Bo Pang
Rijing Liao
Zhijun Tang
Shengjie Guo
Zhuhua Wu
Wen Liu
author_sort Bo Pang
title Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_short Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_full Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_fullStr Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_full_unstemmed Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
title_sort caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2’-bipyridine formation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Caerulomycins and collismycins are two types of 2,2’-bipyridine natural products that are biosynthesized via a hybrid NRPS-PKS pathway, but the details of their biosynthesis were unknown. Here, the authors elucidate their biosynthetic pathways, validate the generality of 2,2’-bipyridine formation, and clarify the process for 2,2’-bipyridine furcation.
url https://doi.org/10.1038/s41467-021-23475-4
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AT rijingliao caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT zhijuntang caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT shengjieguo caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT zhuhuawu caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
AT wenliu caerulomycinandcollismycinantibioticsshareatransactingflavoproteindependentassemblylinefor22bipyridineformation
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