E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 sig...
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Nature Publishing Group
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15865 |
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doaj-fcfe5f0cdf014198b141e4fc270fc7752021-05-11T07:57:49ZengNature Publishing GroupNature Communications2041-17232017-06-018111610.1038/ncomms15865E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDPPradeep Bist0Wan Shoo Cheong1Aylwin Ng2Neha Dikshit3Bae-Hoon Kim4Niyas Kudukkil Pulloor5Hanif Javanmard Khameneh6Matija Hedl7Avinash R. Shenoy8Vanniarajan Balamuralidhar9Najib Bin Abdul Malik10Michelle Hong11Albert Neutzner12Keh-Chuang Chin13Koichi S. Kobayashi14Antonio Bertoletti15Alessandra Mortellaro16Clara Abraham17John D. MacMicking18Ramnik J. Xavier19Bindu Sukumaran20Program in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolGastrointestinal Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolDepartments of Microbial Pathogenesis and Immunobiology, HHMI, Yale Systems Biology Institute, Yale University School of MedicineProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Department of Internal Medicine, Yale University School of MedicineDepartments of Microbial Pathogenesis and Immunobiology, HHMI, Yale Systems Biology Institute, Yale University School of MedicineProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolDepartment of Biomedicine, University Hospital BaselSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science CentreProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Department of Internal Medicine, Yale University School of MedicineDepartments of Microbial Pathogenesis and Immunobiology, HHMI, Yale Systems Biology Institute, Yale University School of MedicineGastrointestinal Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProlonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling.https://doi.org/10.1038/ncomms15865 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran |
| spellingShingle |
Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP Nature Communications |
| author_facet |
Pradeep Bist Wan Shoo Cheong Aylwin Ng Neha Dikshit Bae-Hoon Kim Niyas Kudukkil Pulloor Hanif Javanmard Khameneh Matija Hedl Avinash R. Shenoy Vanniarajan Balamuralidhar Najib Bin Abdul Malik Michelle Hong Albert Neutzner Keh-Chuang Chin Koichi S. Kobayashi Antonio Bertoletti Alessandra Mortellaro Clara Abraham John D. MacMicking Ramnik J. Xavier Bindu Sukumaran |
| author_sort |
Pradeep Bist |
| title |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP |
| title_short |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP |
| title_full |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP |
| title_fullStr |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP |
| title_full_unstemmed |
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP |
| title_sort |
e3 ubiquitin ligase znrf4 negatively regulates nod2 signalling and induces tolerance to mdp |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-06-01 |
| description |
Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF4 is essential for the down-regulation of NOD2 signalling. |
| url |
https://doi.org/10.1038/ncomms15865 |
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