Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines

The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with via...

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Main Authors:	Linn Antberg, Paolo Cifani, Fredrik Levander, Peter James
Format:	Article
Language:	English
Published:	Elsevier 2015-09-01
Series:	EuPA Open Proteomics
Subjects:	DNA repair DNA damage Chemotherapy Breast Cancer Label-free Quantification Pathway-centric analysis Selected reaction monitoring Shotgun proteomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212968515000148

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spelling	doaj-fcfba4cf21504dada78e185da7ee6e6f2020-11-24T22:13:55ZengElsevierEuPA Open Proteomics2212-96852015-09-018C12813610.1016/j.euprot.2015.05.002Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell linesLinn Antberg0Paolo Cifani1Fredrik Levander2Peter James3Department of Immunotechnology, CREATE Health, Lund University, Lund, SwedenDepartment of Immunotechnology, CREATE Health, Lund University, Lund, SwedenDepartment of Immunotechnology, CREATE Health, Lund University, Lund, SwedenDepartment of Immunotechnology, CREATE Health, Lund University, Lund, SwedenThe response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.http://www.sciencedirect.com/science/article/pii/S2212968515000148DNA repairDNA damageChemotherapyBreast CancerLabel-free QuantificationPathway-centric analysisSelected reaction monitoringShotgun proteomics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Linn Antberg Paolo Cifani Fredrik Levander Peter James
spellingShingle	Linn Antberg Paolo Cifani Fredrik Levander Peter James Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines EuPA Open Proteomics DNA repair DNA damage Chemotherapy Breast Cancer Label-free Quantification Pathway-centric analysis Selected reaction monitoring Shotgun proteomics
author_facet	Linn Antberg Paolo Cifani Fredrik Levander Peter James
author_sort	Linn Antberg
title	Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
title_short	Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
title_full	Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
title_fullStr	Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
title_full_unstemmed	Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines
title_sort	pathway-centric analysis of the dna damage response to chemotherapeutic agents in two breast cell lines
publisher	Elsevier
series	EuPA Open Proteomics
issn	2212-9685
publishDate	2015-09-01
description	The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.
topic	DNA repair DNA damage Chemotherapy Breast Cancer Label-free Quantification Pathway-centric analysis Selected reaction monitoring Shotgun proteomics
url	http://www.sciencedirect.com/science/article/pii/S2212968515000148
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Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines

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