Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile

Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile

Runt-related transcription factor-3 (Runx3) is a tumor suppressor, and its contribution to melanoma progression remains unclear. We previously demonstrated that Runx3 re-expression in B16-F10 melanoma cells changed their shape and attenuated their migration. In this study, we found that Runx3 re-exp...

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Bibliographic Details
Main Authors: Ning Wang, Haiying Zhang, Xiulin Cui, Chao Ma, Linghui Wang, Wenguang Liu
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Runx3
melanoma
metastasis
extracellular matrix
adhesion
actin cytoskeleton
Online Access:https://www.mdpi.com/1422-0067/22/4/2219

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