Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular fun...

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Bibliographic Details
Main Authors: Haixia Zhao, Xu You, Qian Chen, Siqi Yang, Qiongyan Ma, Yumin He, Chaoqi Liu, Yaoyan Dun, Jie Wu, Changcheng Zhang, Ding Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Sertoli cell
ERα/Nrf2
icariin
testis
aging
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00677/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00677/full

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