Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occ...

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Bibliographic Details
Main Authors: Hai-Ying Cui, Xiang-Jian Zhang, Yi Yang, Cong Zhang, Chun-Hua Zhu, Jiang-Yong Miao, Rong Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
cerebral ischemia/reperfusion; rosmarinic acid; cellular apoptosis; oxidative injury; neuroprotection; Bcl-2; Bax; Nrf2; heme oxygenase 1; PI3K/Akt signal pathway; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2119;epage=2128;aulast=Cui

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2119;epage=2128;aulast=Cui

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