Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans
African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomark...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/538017 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dianne M. Babbitt Keith M. Diaz Deborah L. Feairheller Kathleen M. Sturgeon Amanda M. Perkins Praveen Veerabhadrappa Sheara T. Williamson Jan Kretzschmar Chenyi Ling Hojun Lee Heather Grimm Sunny R. Thakkar Deborah L. Crabbe Mohammed A. Kashem Michael D. Brown |
| spellingShingle |
Dianne M. Babbitt Keith M. Diaz Deborah L. Feairheller Kathleen M. Sturgeon Amanda M. Perkins Praveen Veerabhadrappa Sheara T. Williamson Jan Kretzschmar Chenyi Ling Hojun Lee Heather Grimm Sunny R. Thakkar Deborah L. Crabbe Mohammed A. Kashem Michael D. Brown Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans International Journal of Hypertension |
| author_facet |
Dianne M. Babbitt Keith M. Diaz Deborah L. Feairheller Kathleen M. Sturgeon Amanda M. Perkins Praveen Veerabhadrappa Sheara T. Williamson Jan Kretzschmar Chenyi Ling Hojun Lee Heather Grimm Sunny R. Thakkar Deborah L. Crabbe Mohammed A. Kashem Michael D. Brown |
| author_sort |
Dianne M. Babbitt |
| title |
Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans |
| title_short |
Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans |
| title_full |
Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans |
| title_fullStr |
Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans |
| title_full_unstemmed |
Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African Americans |
| title_sort |
endothelial activation microparticles and inflammation status improve with exercise training in african americans |
| publisher |
Hindawi Limited |
| series |
International Journal of Hypertension |
| issn |
2090-0384 2090-0392 |
| publishDate |
2013-01-01 |
| description |
African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing. Participants engaged in 6 months of AEXT. Following the AEXT intervention, all baseline tests were repeated. FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT. Changes in inflammatory biomarkers did not significantly predict the change in FMD. The change in VO2 max significantly predicted the change in IL-10. Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans. |
| url |
http://dx.doi.org/10.1155/2013/538017 |
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doaj-fcdd3776e6d34b5b94bcc6e9f296e5e02020-11-24T23:49:57ZengHindawi LimitedInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/538017538017Endothelial Activation Microparticles and Inflammation Status Improve with Exercise Training in African AmericansDianne M. Babbitt0Keith M. Diaz1Deborah L. Feairheller2Kathleen M. Sturgeon3Amanda M. Perkins4Praveen Veerabhadrappa5Sheara T. Williamson6Jan Kretzschmar7Chenyi Ling8Hojun Lee9Heather Grimm10Sunny R. Thakkar11Deborah L. Crabbe12Mohammed A. Kashem13Michael D. Brown14Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USADivision of Cardiology, Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140, USADivision of Cardiology, Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140, USAHypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 N. Broad Street, Philadelphia, PA 19122, USAAfrican Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing. Participants engaged in 6 months of AEXT. Following the AEXT intervention, all baseline tests were repeated. FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT. Changes in inflammatory biomarkers did not significantly predict the change in FMD. The change in VO2 max significantly predicted the change in IL-10. Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans.http://dx.doi.org/10.1155/2013/538017 |