Dopamine receptor D2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK

Dopamine receptor D2 activation suppresses the radiosensitizing effect of aripiprazole via activation of AMPK

Drug repositioning has garnered attention as an alternative strategy to the discovery and development of novel anticancer drug candidates. In this study, we screened 321 FDA‐approved drugs against nonirradiated and irradiated MCF‐7 cells, revealing that aripiprazole, a dopamine receptor D2 (D2R) par...

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Bibliographic Details
Main Authors: Hyounji Lee, Seongman Kang, Jong Kyung Sonn, Young‐Bin Lim
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:FEBS Open Bio
Subjects:
AMPK
breast cancer
dopamine receptor
drug repositioning
radiotherapy
Online Access:https://doi.org/10.1002/2211-5463.12699

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