Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Abstract Background Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of cancer cells. However, the potential anti-tumour effects of T-96 ag...

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Bibliographic Details
Main Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang, Zhong-zhu Chen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Biological Research
Subjects:
T-96
CaP
ER stress
Apoptosis
Autophagic flux
Cisplatin
Online Access:https://doi.org/10.1186/s40659-021-00350-6

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