Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-rea...

Full description

Bibliographic Details
Main Authors: Yu Adachi, Keisuke Tonouchi, Arnone Nithichanon, Masayuki Kuraoka, Akiko Watanabe, Ryo Shinnakasu, Hideki Asanuma, Akira Ainai, Yusuke Ohmi, Takuya Yamamoto, Ken J. Ishii, Hideki Hasegawa, Haruko Takeyama, Ganjana Lertmemongkolchai, Tomohiro Kurosaki, Manabu Ato, Garnett Kelsoe, Yoshimasa Takahashi
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11821-6
id doaj-fcc9b042359d4d5ca91778a784a13526
record_format Article
spelling doaj-fcc9b042359d4d5ca91778a784a135262021-05-11T12:38:34ZengNature Publishing GroupNature Communications2041-17232019-08-0110111310.1038/s41467-019-11821-6Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodiesYu Adachi0Keisuke Tonouchi1Arnone Nithichanon2Masayuki Kuraoka3Akiko Watanabe4Ryo Shinnakasu5Hideki Asanuma6Akira Ainai7Yusuke Ohmi8Takuya Yamamoto9Ken J. Ishii10Hideki Hasegawa11Haruko Takeyama12Ganjana Lertmemongkolchai13Tomohiro Kurosaki14Manabu Ato15Garnett Kelsoe16Yoshimasa Takahashi17Department of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, Duke UniversityDepartment of Immunology, Duke UniversityLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka UniversityInfluenza Virus Research Center, National Institute of Infectious DiseasesDepartment of Pathology, National Institute of Infectious DiseasesDepartment of Clinical Engineering, Chubu University College of Life and Health SciencesLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and NutritionCenter for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and NutritionInfluenza Virus Research Center, National Institute of Infectious DiseasesDepartment of Life Science and Medical Bioscience, Waseda UniversityCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen UniversityLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka UniversityDepartment of Mycobacteriology, National Institute of Infectious DiseasesDepartment of Immunology, Duke UniversityDepartment of Immunology, National Institute of Infectious DiseasesAntibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.https://doi.org/10.1038/s41467-019-11821-6
collection DOAJ
language English
format Article
sources DOAJ
author Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
spellingShingle Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
Nature Communications
author_facet Yu Adachi
Keisuke Tonouchi
Arnone Nithichanon
Masayuki Kuraoka
Akiko Watanabe
Ryo Shinnakasu
Hideki Asanuma
Akira Ainai
Yusuke Ohmi
Takuya Yamamoto
Ken J. Ishii
Hideki Hasegawa
Haruko Takeyama
Ganjana Lertmemongkolchai
Tomohiro Kurosaki
Manabu Ato
Garnett Kelsoe
Yoshimasa Takahashi
author_sort Yu Adachi
title Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_short Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_full Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_fullStr Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_full_unstemmed Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
title_sort exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.
url https://doi.org/10.1038/s41467-019-11821-6
work_keys_str_mv AT yuadachi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT keisuketonouchi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT arnonenithichanon exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT masayukikuraoka exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT akikowatanabe exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT ryoshinnakasu exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT hidekiasanuma exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT akiraainai exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT yusukeohmi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT takuyayamamoto exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT kenjishii exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT hidekihasegawa exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT harukotakeyama exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT ganjanalertmemongkolchai exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT tomohirokurosaki exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT manabuato exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT garnettkelsoe exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
AT yoshimasatakahashi exposureofanoccludedhemagglutininepitopedrivesselectionofaclassofcrossprotectiveinfluenzaantibodies
_version_ 1721444540051619840