Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies
Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-rea...
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2019-08-01
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doaj-fcc9b042359d4d5ca91778a784a135262021-05-11T12:38:34ZengNature Publishing GroupNature Communications2041-17232019-08-0110111310.1038/s41467-019-11821-6Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodiesYu Adachi0Keisuke Tonouchi1Arnone Nithichanon2Masayuki Kuraoka3Akiko Watanabe4Ryo Shinnakasu5Hideki Asanuma6Akira Ainai7Yusuke Ohmi8Takuya Yamamoto9Ken J. Ishii10Hideki Hasegawa11Haruko Takeyama12Ganjana Lertmemongkolchai13Tomohiro Kurosaki14Manabu Ato15Garnett Kelsoe16Yoshimasa Takahashi17Department of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, National Institute of Infectious DiseasesDepartment of Immunology, Duke UniversityDepartment of Immunology, Duke UniversityLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka UniversityInfluenza Virus Research Center, National Institute of Infectious DiseasesDepartment of Pathology, National Institute of Infectious DiseasesDepartment of Clinical Engineering, Chubu University College of Life and Health SciencesLaboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and NutritionCenter for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and NutritionInfluenza Virus Research Center, National Institute of Infectious DiseasesDepartment of Life Science and Medical Bioscience, Waseda UniversityCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen UniversityLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka UniversityDepartment of Mycobacteriology, National Institute of Infectious DiseasesDepartment of Immunology, Duke UniversityDepartment of Immunology, National Institute of Infectious DiseasesAntibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.https://doi.org/10.1038/s41467-019-11821-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Adachi Keisuke Tonouchi Arnone Nithichanon Masayuki Kuraoka Akiko Watanabe Ryo Shinnakasu Hideki Asanuma Akira Ainai Yusuke Ohmi Takuya Yamamoto Ken J. Ishii Hideki Hasegawa Haruko Takeyama Ganjana Lertmemongkolchai Tomohiro Kurosaki Manabu Ato Garnett Kelsoe Yoshimasa Takahashi |
spellingShingle |
Yu Adachi Keisuke Tonouchi Arnone Nithichanon Masayuki Kuraoka Akiko Watanabe Ryo Shinnakasu Hideki Asanuma Akira Ainai Yusuke Ohmi Takuya Yamamoto Ken J. Ishii Hideki Hasegawa Haruko Takeyama Ganjana Lertmemongkolchai Tomohiro Kurosaki Manabu Ato Garnett Kelsoe Yoshimasa Takahashi Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies Nature Communications |
author_facet |
Yu Adachi Keisuke Tonouchi Arnone Nithichanon Masayuki Kuraoka Akiko Watanabe Ryo Shinnakasu Hideki Asanuma Akira Ainai Yusuke Ohmi Takuya Yamamoto Ken J. Ishii Hideki Hasegawa Haruko Takeyama Ganjana Lertmemongkolchai Tomohiro Kurosaki Manabu Ato Garnett Kelsoe Yoshimasa Takahashi |
author_sort |
Yu Adachi |
title |
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
title_short |
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
title_full |
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
title_fullStr |
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
title_full_unstemmed |
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
title_sort |
exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-08-01 |
description |
Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies. |
url |
https://doi.org/10.1038/s41467-019-11821-6 |
work_keys_str_mv |
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