Current Therapeutic Strategies in BRAF-Mutant Metastatic Colorectal Cancer

Current Therapeutic Strategies in BRAF-Mutant Metastatic Colorectal Cancer

Around 8–12% of patients with advanced colon rectal cancer (CRC) present with BRAF alterations, in particular V600E mutation, which is associated with right-side, poorly differentiated and mucinous type tumors. The presence of BRAF mutation (BRAF-mt) has been identified as a hallmark of poor prognos...

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Bibliographic Details
Main Authors: Elisa Grassi, Jody Corbelli, Giorgio Papiani, Maria Aurelia Barbera, Federica Gazzaneo, Stefano Tamberi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
BRAF mutation
microsatellites instability
targeted therapy
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.601722/full

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