IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.

Excitotoxicity is a major component of neurodegenerative diseases and is typically accompanied by an inflammatory response. Cytokines IL-1alpha and IL-1beta are key regulators of this inflammatory response and modulate the activity of numerous cell types, including neurons. IL-1RAcPb is an isoform o...

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Bibliographic Details
Main Authors: David eGosselin, Marc-Andre eBellavance, Serge eRivest
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Calcium
Interleukin-1
Kainic Acid
excitotoxicity
Neuronal Death
calpastatin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00009/full

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