Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Excessive miR-25-3p maturation via N 6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Cigarette smoke induces microRNA dysregulation in cancers. Here, the authors show that cigarette smoke promotes the maturation of oncogenic primary miR-25 due to METTL3 hypomethylation, and mature miR-25 suppresses PH domain leucine-rich repeat protein phosphatase 2, resulting in oncogenic AKT activ...

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Bibliographic Details
Main Authors: Jialiang Zhang, Ruihong Bai, Mei Li, Huilin Ye, Chen Wu, Chengfeng Wang, Shengping Li, Liping Tan, Dongmei Mai, Guolin Li, Ling Pan, Yanfen Zheng, Jiachun Su, Ying Ye, Zhiqiang Fu, Shangyou Zheng, Zhixiang Zuo, Zexian Liu, Qi Zhao, Xu Che, Dan Xie, Weihua Jia, Mu-Sheng Zeng, Wen Tan, Rufu Chen, Rui-Hua Xu, Jian Zheng, Dongxin Lin
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09712-x

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