Regulation of MicroRNA Biogenesis: A miRiad of mechanisms

<p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the l...

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Main Authors: Davis Brandi N, Hata Akiko
Format: Article
Language:English
Published: BMC 2009-08-01
Series:Cell Communication and Signaling
Online Access:http://www.biosignaling.com/content/7/1/18
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spelling doaj-fcab079cb83e494ab8c1de85f295cf472020-11-24T22:01:01ZengBMCCell Communication and Signaling1478-811X2009-08-01711810.1186/1478-811X-7-18Regulation of MicroRNA Biogenesis: A miRiad of mechanismsDavis Brandi NHata Akiko<p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.</p> http://www.biosignaling.com/content/7/1/18
collection DOAJ
language English
format Article
sources DOAJ
author Davis Brandi N
Hata Akiko
spellingShingle Davis Brandi N
Hata Akiko
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
Cell Communication and Signaling
author_facet Davis Brandi N
Hata Akiko
author_sort Davis Brandi N
title Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
title_short Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
title_full Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
title_fullStr Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
title_full_unstemmed Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
title_sort regulation of microrna biogenesis: a miriad of mechanisms
publisher BMC
series Cell Communication and Signaling
issn 1478-811X
publishDate 2009-08-01
description <p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.</p>
url http://www.biosignaling.com/content/7/1/18
work_keys_str_mv AT davisbrandin regulationofmicrornabiogenesisamiriadofmechanisms
AT hataakiko regulationofmicrornabiogenesisamiriadofmechanisms
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