Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
<p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the l...
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doaj-fcab079cb83e494ab8c1de85f295cf472020-11-24T22:01:01ZengBMCCell Communication and Signaling1478-811X2009-08-01711810.1186/1478-811X-7-18Regulation of MicroRNA Biogenesis: A miRiad of mechanismsDavis Brandi NHata Akiko<p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.</p> http://www.biosignaling.com/content/7/1/18 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Davis Brandi N Hata Akiko |
spellingShingle |
Davis Brandi N Hata Akiko Regulation of MicroRNA Biogenesis: A miRiad of mechanisms Cell Communication and Signaling |
author_facet |
Davis Brandi N Hata Akiko |
author_sort |
Davis Brandi N |
title |
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms |
title_short |
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms |
title_full |
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms |
title_fullStr |
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms |
title_full_unstemmed |
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms |
title_sort |
regulation of microrna biogenesis: a miriad of mechanisms |
publisher |
BMC |
series |
Cell Communication and Signaling |
issn |
1478-811X |
publishDate |
2009-08-01 |
description |
<p>Abstract</p> <p>microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.</p> |
url |
http://www.biosignaling.com/content/7/1/18 |
work_keys_str_mv |
AT davisbrandin regulationofmicrornabiogenesisamiriadofmechanisms AT hataakiko regulationofmicrornabiogenesisamiriadofmechanisms |
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1725842200619646976 |