Magnoflorine Alleviates “M1” Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome

Magnoflorine Alleviates “M1” Polarized Macrophage-Induced Intervertebral Disc Degeneration Through Repressing the HMGB1/Myd88/NF-κB Pathway and NLRP3 Inflammasome

Intervertebral disc degeneration (IDD) is related to the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. The imbalance of pro-inflammatory (M1 type) and anti-inflammatory (M2 type) macrophages contributes to maintaining tissue integrity. Here, we a...

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Bibliographic Details
Main Authors: Feng Zhao, Zhenye Guo, Fushan Hou, Wei Fan, Binqiang Wu, Zhonglai Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
magnoflorine
macrophages
nucleus pulposus cells
intervertebral disc degeneration
inflammatory response
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.701087/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.701087/full

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