Association of the Single Nucleotide Polymorphisms of the Genes Encoding IL-2 and IFN-γ With Febrile Seizure

• Main Authors: Amin Shahrokhi, Ameneh Zare-Shahabadi, Mohammad Naeimi Poor, Firouzeh Sajedi, Samaneh Soltani, Samaneh Zoghi, Reza Shervin Badv, Mahmoud Reza Ashrafi, Nima Rezaei
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2017-08-01
• Series: Acta Medica Iranica
• Subjects: Febrile seizure; Gene polymorphisms; Interleukin-2; IFN-γ; Etiology
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/5713
• ISSN: 0044-6025; 1735-9694

Inflammatory elements and genetics have major roles in febrile seizures (FS) pathogenesis. Seventy patients were enrolled and compared with 139 controls. The allele and genotype frequency of the IL-2 gene at -330 and +166 positions and the IFN-γ at +874 position were determined. A significant positive association with GG genotype at position -330 in the patient group was found (P=0.003). Further, a positive association was detected in simple and complex FS groups at the same position (P=0.03, P=0.004). IL-2 GT haplotype was significantly more common in the patients compared to controls (P=0.0008). Higher frequency of GT haplotype was detected in simple FS patients in comparison to controls (P=0.0003). Contrary, IL-2 TG haplotype frequency was lower in complex FS group (P=0.005). Overrepresentation of certain alleles, genotypes and haplotypes in IL-2 gene in FS patients could predispose individuals to this disease.