Congenital cutaneous kaposiform hemangioendothelioma in a newborn calf

• Main Authors: Erkmen Tuğrul Epikmen, Ahmet Aydogan, Hamdi Avci, Sümbül Serap Birincioğlu
• Format: Article
• Language: English
• Published: Ss.Cyril and Methodius University, Skopje 2020-10-01
• Series: Macedonian Veterinary Review
• Subjects: kaposiform hemangioendothelioma; pathology; immunohistochemistry; new-born calf
• Online Access: https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2020_0018

A one-day-old female Holstein calf was presented with subcutaneous masses spread over the whole body. Macroscopically, the masses were firm in touch, greyish-white in colour, 0.5-2 cm in diameter range. Histopathological examination confirmed the cutaneous Kaposiform hemangioendothelioma (KHE). Microscopic examination of the tumor revealed sheets of spindled endothelial cells forming vascular slits. Immunohistochemically, the tumor cells and capillaries gave strongly positive reaction for CD31 while vimentin, alpha smooth muscle actin and cytokeratin AE1/AE3 were negative. In this case, macroscopical, detailed histhopathological and immunohistochemical findings of congenital KHE reported firstly in a newborn calf.