Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection

Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection

C-reactive protein (CRP), a component of the innate immune system, is an antipneumococcal plasma protein. Human CRP has been shown to protect mice against infection with lethal doses of Streptococcus pneumoniae by decreasing bacteremia. in vitro, CRP binds to phosphocholine-containing substances, su...

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Bibliographic Details
Main Authors: Sanjay K. Singh, Donald N. Ngwa, Alok Agrawal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein
acute phase response
complement
inflammation
pneumococcal infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01812/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01812/full

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