Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoi...

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Main Authors:	Jiang-Fei Li, Wei-Wei Xu, Rong-Hua Wang, Yue Li, Ge Yin, Mengchun Ye
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23371-x

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spelling	doaj-fc9481d72a2f432a9bd1db33338142502021-05-30T11:14:19ZengNature Publishing GroupNature Communications2041-17232021-05-011211910.1038/s41467-021-23371-xConstruction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazolesJiang-Fei Li0Wei-Wei Xu1Rong-Hua Wang2Yue Li3Ge Yin4Mengchun Ye5State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityTransition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.https://doi.org/10.1038/s41467-021-23371-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye
spellingShingle	Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles Nature Communications
author_facet	Jiang-Fei Li Wei-Wei Xu Rong-Hua Wang Yue Li Ge Yin Mengchun Ye
author_sort	Jiang-Fei Li
title	Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_short	Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_full	Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_fullStr	Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_full_unstemmed	Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles
title_sort	construction 7-membered ring via ni–al bimetal-enabled c–h cyclization for synthesis of tricyclic imidazoles
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.
url	https://doi.org/10.1038/s41467-021-23371-x
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Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

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