Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined human hypothalamic BDNF expression in association with 44...

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Bibliographic Details
Main Authors: Zongyang Mou, Thomas M. Hyde, Barbara K. Lipska, Keri Martinowich, Peter Wei, Chiew-Jen Ong, Lindsay A. Hunter, Gladys I. Palaguachi, Eva Morgun, Rujia Teng, Chen Lai, Tania A. Condarco, Andrew P. Demidowich, Amanda J. Krause, Leslie J. Marshall, Karin Haack, V. Saroja Voruganti, Shelley A. Cole, Nancy F. Butte, Anthony G. Comuzzie, Michael A. Nalls, Alan B. Zonderman, Andrew B. Singleton, Michele K. Evans, Bronwen Martin, Stuart Maudsley, Jack W. Tsao, Joel E. Kleinman, Jack A. Yanovski, Joan C. Han
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Subjects:
Mou et al. show that brain-derived neurotrophic factor (BDNF) rs12291063 minor C allele disrupts binding and transactivation by the transcriptional regulator
heterogeneous nuclear ribonucleoprotein D0B
and it is associated with lower ventromedial hypothalamic BDNF expression and obesity. BDNF augmentation may be specifically beneficial for treating obesity in individuals with the CC genotype
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011079

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http://www.sciencedirect.com/science/article/pii/S2211124715011079

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