Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C

Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C

Type 2 diabetes mellitus (T2DM) is often associated with hepatitis C virus (HCV) infection. Successful HCV treatment may improve glycemic control and potentially induce remission of T2DM. We report a case of an obese 52-year-old woman with mixed genotype 1a/1b HCV infection with compensated cirrhosi...

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Main Authors: Raymond Anthony Pashun, Nicole T. Shen, Arun Jesudian
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Hepatology
Online Access:http://dx.doi.org/10.1155/2016/7807921
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spelling doaj-fc88a5d84737424c88e20e99d0f478832020-11-24T20:41:24ZengHindawi LimitedCase Reports in Hepatology2090-65872090-65952016-01-01201610.1155/2016/78079217807921Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis CRaymond Anthony Pashun0Nicole T. Shen1Arun Jesudian2Department of Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, Suite 450, New York, NY 10021, USADepartment of Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, Suite 450, New York, NY 10021, USADivision of Gastroenterology and Hepatology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, 1305 York Avenue, 4th Floor, New York, NY 10021, USAType 2 diabetes mellitus (T2DM) is often associated with hepatitis C virus (HCV) infection. Successful HCV treatment may improve glycemic control and potentially induce remission of T2DM. We report a case of an obese 52-year-old woman with mixed genotype 1a/1b HCV infection with compensated cirrhosis and a 10-year history of poorly controlled T2DM on insulin therapy. Following successful therapy with sofosbuvir, simeprevir, and ribavirin, her insulin requirements decreased and her glycosylated hemoglobin (HgA1c) normalized despite weight gain. This case suggests an association between HCV and T2DM and the potential for significant improvement in glycemic control with eradication of HCV.http://dx.doi.org/10.1155/2016/7807921
collection DOAJ
language English
format Article
sources DOAJ
author Raymond Anthony Pashun
Nicole T. Shen
Arun Jesudian
spellingShingle Raymond Anthony Pashun
Nicole T. Shen
Arun Jesudian
Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
Case Reports in Hepatology
author_facet Raymond Anthony Pashun
Nicole T. Shen
Arun Jesudian
author_sort Raymond Anthony Pashun
title Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
title_short Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
title_full Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
title_fullStr Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
title_full_unstemmed Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C
title_sort markedly improved glycemic control in poorly controlled type 2 diabetes following direct acting antiviral treatment of genotype 1 hepatitis c
publisher Hindawi Limited
series Case Reports in Hepatology
issn 2090-6587
2090-6595
publishDate 2016-01-01
description Type 2 diabetes mellitus (T2DM) is often associated with hepatitis C virus (HCV) infection. Successful HCV treatment may improve glycemic control and potentially induce remission of T2DM. We report a case of an obese 52-year-old woman with mixed genotype 1a/1b HCV infection with compensated cirrhosis and a 10-year history of poorly controlled T2DM on insulin therapy. Following successful therapy with sofosbuvir, simeprevir, and ribavirin, her insulin requirements decreased and her glycosylated hemoglobin (HgA1c) normalized despite weight gain. This case suggests an association between HCV and T2DM and the potential for significant improvement in glycemic control with eradication of HCV.
url http://dx.doi.org/10.1155/2016/7807921
work_keys_str_mv AT raymondanthonypashun markedlyimprovedglycemiccontrolinpoorlycontrolledtype2diabetesfollowingdirectactingantiviraltreatmentofgenotype1hepatitisc
AT nicoletshen markedlyimprovedglycemiccontrolinpoorlycontrolledtype2diabetesfollowingdirectactingantiviraltreatmentofgenotype1hepatitisc
AT arunjesudian markedlyimprovedglycemiccontrolinpoorlycontrolledtype2diabetesfollowingdirectactingantiviraltreatmentofgenotype1hepatitisc
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