Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells

Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells

Syndecan-4 (SDC4) is a cell-surface proteoglycan associated with cell adhesion, motility, and intracellular signaling. Here, we present that SDC4 functions as a positive regulator of the transforming growth factor (TGF)-β1-induced epithelial to mesenchymal transition (EMT) via Snail in lung adenocar...

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Bibliographic Details
Main Authors: Yoko Toba-Ichihashi, Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Syndecan-4
Transforming growth factor-β 1
Epithelial to mesenchymal transition
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405580815001417

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