Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase

Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase

In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor. Dysregulation of D-serine brain levels in humans has been associated with neurodegenerative and psychiatric disorders. This D...

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Bibliographic Details
Main Authors: Silvia Sacchi, Valentina Rabattoni, Matteo Miceli, Loredano Pollegioni
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
D-serine
flavoprotein
nitrosylation
phosphorylation
biochemical properties
sulfhydration
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.684934/full

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