Effect of intravitreal injection with small interfering RNA targeting hypoxia inducible factor-1α on vascular endothelial growth factor protein expression in diabetic rats

Effect of intravitreal injection with small interfering RNA targeting hypoxia inducible factor-1α on vascular endothelial growth factor protein expression in diabetic rats

AIM: To evaluate the inhibitory effect of hypoxia inducible factor-1α(HIF-1α)small interfering RNA(siRNA)on the expression of vascular endothelial growth factor(VEGF)protein and explore the feasibility of potential therapeutic approach for diabetic neovascular disease.<p>METHODS: Using pSilenc...

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Bibliographic Details
Main Authors: Li-Zhu Meng, Song Chen, Lei Chen, Yan Liu, Jin-Yong Lin, Yu-Chuan Wang, Mei Han
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2015-10-01
Series:Guoji Yanke Zazhi
Subjects:
hypoxia inducible factor-1
vascular endothelial growth factor
RNA interfering
retinal neovascularization
gene therapy
Online Access:http://ies.ijo.cn/cn_publish/2015/10/201510006.pdf

Internet

http://ies.ijo.cn/cn_publish/2015/10/201510006.pdf

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