Mitochondrial Complex I Core Protein Regulates cAMP Signaling via Phosphodiesterase Pde2 and NAD Homeostasis in Candida albicans

Mitochondrial Complex I Core Protein Regulates cAMP Signaling via Phosphodiesterase Pde2 and NAD Homeostasis in Candida albicans

The cyclic adenosine 3′,5′-monophosphate (cAMP)/protein kinase A (PKA) pathway of Candida albicans responds to nutrient availability to coordinate a series of cellular processes for its replication and survival. The elevation of cAMP for PKA signaling must be both transitory and tightly regulated. O...

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Bibliographic Details
Main Authors: Xiaodong She, Lulu Zhang, Jingwen Peng, Jingyun Zhang, Hongbin Li, Pengyi Zhang, Richard Calderone, Weida Liu, Dongmei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
mitochondrial complex I
ergosterol synthesis
NADH/NAD+ redox state
PDE2 regulation
Candida albicans
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.559975/full

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