Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation

Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation

(1) Background: Traumatic brain injury (TBI) frequently occurs worldwide, resulting in high morbidity and mortality. Here, we hypothesized that TBI impairs an autoregulatory mechanism, namely the flow-induced constriction of isolated rat middle cerebral arteries (MCAs). (2) Methods: TBI was induced...

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Bibliographic Details
Main Authors: Annamaria Szenasi, Krisztina Amrein, Endre Czeiter, Nikolett Szarka, Peter Toth, Akos Koller
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
hemodynamic forces
diameter
autoregulation
arachidonic acid
CYP450 4A
TXA<sub>2</sub> receptors
Online Access:https://www.mdpi.com/1422-0067/22/12/6624

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https://www.mdpi.com/1422-0067/22/12/6624

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