Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer

Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer

The immunosuppressive tumor microenvironment (TME) of cancer strongly hinders the anti-tumor immune responses, thereby resulting in disappointing responses to immunotherapy. Chemoattractive and promotive traits of chemokines exerted on leukocytes have garnered interest in improving the efficiency of...

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Bibliographic Details
Main Authors: Wen Nie, Ting Yu, Xiaoxiao Liu, Bilan Wang, Tingting Li, Yin Wu, Xikun Zhou, Lu Ma, Yunfeng Lin, Zhiyong Qian, Xiang Gao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-11-01
Series:Bioactive Materials
Subjects:
Cancer
Immunogene therapy
CKb11
Nanocomposites
Macrophages polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21001419

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http://www.sciencedirect.com/science/article/pii/S2452199X21001419

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