Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.

Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.

Calpain, a calcium-dependent cysteine protease, is reportedly involved in the pathophysiology of autoimmune diseases such as rheumatoid arthritis (RA). In addition, autoantibodies against calpastatin, a natural and specific inhibitor of calpain, are widely observed in RA. We previously reported that...

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Bibliographic Details
Main Authors: Mikiko Iguchi-Hashimoto, Takashi Usui, Hajime Yoshifuji, Masakazu Shimizu, Shio Kobayashi, Yoshinaga Ito, Kosaku Murakami, Aoi Shiomi, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203168?pdf=render

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