Studies on perchlorate levels in powdered infant formulas available on the Polish market

• Main Authors: Nizinski Przemyslaw, Wisniewska Patrycja, Kulinowska Magdalena, Blazewicz Anna
• Format: Article
• Language: English
• Published: Sciendo 2021-06-01
• Series: Current Issues in Pharmacy and Medical Sciences
• Subjects: ion chromatography; endocrine disruptors; risk assessment; human health
• Online Access: https://doi.org/10.2478/cipms-2021-0013

Perchlorate has been acknowledged as a health threat due to its ability to interfere with iodine uptake by the thyroid gland. Infants and developing newborns have been considered as the most vulnerable groups to the perchlorate toxicity. A crucial source of perchlorate ingestion are powdered infant formulas. This study was designed to measure perchlorate content in thirty-one powdered infant formulas available on the Polish market. A rapid and sensitive ion chromatography method – conductivity cell detection – was applied to determine ClO4−{\rm{ClO}}_4^ - content. Limit of detection (0.150 µg/L) and limit of quantification (0.450 µg/L) were assessed. Collected samples were classified by the age of consumers: first stage, until the baby is six months old and follow-on formula for older children. Geometric mean of perchlorate concentration of 1.041 µg/L and 0.857 µg/L in the groups of the first stage and follow-on formulas were calculated, respectively. A health risk assessment revealed that the Tolerable Daily Intake (TDI) for perchlorate (0.3 µg/kg body weight/day) was exceeded only in a few milk samples. The findings suggest that perchlorate contamination of powdered infant formulas may not to be an immediate health issue, yet testing for ClO4−{\rm{ClO}}_4^ - should continuously be conducted. To the best of our knowledge, this is the first study concerning perchlorate content in infant formulas in Poland.