Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity

Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity

Cerium oxide nanoparticles (CNPs) are potent radical scavengers protecting cells from oxidative insults, including ionizing radiation. Here we show that CNPs prevent X-ray-induced oxidative imbalance reducing DNA breaks on HaCat keratinocytes, nearly abating mutagenesis. At the same time, and in spi...

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Bibliographic Details
Main Authors: Fanny Caputo, Anna Giovanetti, Francesca Corsi, Vittoria Maresca, Stefania Briganti, Silvia Licoccia, Enrico Traversa, Lina Ghibelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
cerium oxide nanoparticles
apoptosis
radio-sensitization
DNA damage response
anticancer therapy
DNA integrity checkpoints
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01183/full

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