Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway

Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway

Electroacupuncture produces analgesia in chronic pain patients and animal models of pain hypersensitivity. The current study aims to illustrate the mechanisms underlying electroacupuncture-attenuated neuropathic pain. Neuropathic rats, induced by tight ligation of L5/L6 spinal nerves, markedly reduc...

Full description

Bibliographic Details
Main Authors:	Usman Ali, Evhy Apryani, Hai-Yun Wu, Xiao-Fang Mao, Hao Liu, Yong-Xiang Wang
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Electroacupuncture Neuropathic pain Spinal cord Microglia IL-10 β-endorphin
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332220300883

Similar Items

Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway
by: Xiao-Fang Mao, et al.
Published: (2019-04-01)

The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors
by: Evhy Apryani, et al.
Published: (2020-02-01)

Effect of electroacupuncture at distal–proximal acupoint combinations on spinal interleukin-1 beta in a rat model of neuropathic pain
by: Huili Jiang, et al.
Published: (2015-01-01)

Repeated electroacupuncture treatment attenuated hyperalgesia through suppression of spinal glial activation in chronic neuropathic pain rats
by: Jun-ying Wang, et al.
Published: (2018-02-01)

Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes
by: Qiao-Qiao Han, et al.
Published: (2021-01-01)

Pain Relief Dependent on IL-17–CD4+ T Cell–β-Endorphin Axis in Rat Model of Brachial Plexus Root Avulsion After Electroacupuncture Therapy
by: Zihang Xu, et al.
Published: (2021-02-01)

Proteomic Identification of an Upregulated Isoform of Annexin A3 in the Spinal Cords of Rats in a Neuropathic Pain Model
by: Wangyuan Zou, et al.
Published: (2017-09-01)

Electroacupuncture Modulates Spinal BDNF/TrκB Signaling Pathway and Ameliorates the Sensitization of Dorsal Horn WDR Neurons in Spared Nerve Injury Rats
by: Meng Xue, et al.
Published: (2020-09-01)

Neuropathic Pain Creates Systemic Ultrastructural Changes in the Nervous System Corrected by Electroacupuncture but Not by Pregabalin
by: Gao L, et al.
Published: (2021-09-01)

Synaptotagmin 1 Is Involved in Neuropathic Pain and Electroacupuncture-Mediated Analgesic Effect
by: Juan Wan, et al.
Published: (2020-01-01)

Plasma levels of beta-endorphin and serotonin in response to specific spinal based exercises
by: O. Sokunbi, et al.
Published: (2008-01-01)

P2X4 receptors and neuropathic pain
by: Makoto eTsuda, et al.
Published: (2013-10-01)

Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord
by: William Galbavy, et al.
Published: (2017-04-01)

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala
by: Xue-Hui Zhang, et al.
Published: (2021-05-01)

Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment
by: Xiangmei Yu, et al.
Published: (2021-06-01)

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice
by: Hsien-Yin Liao, et al.
Published: (2021-06-01)

Biopsychosocial characteristics of patients with neuropathic pain following spinal cord trauma injury. Case reports
by: Viviana Gonçalves Silva, et al.

Is functional state of spinal microglia involved in the anti-allodynic and anti-hyperalgesic effects of electroacupuncture in rat model of monoarthritis?
by: Sun Shan, et al.
Published: (2007-06-01)

Fractalkine/CX3CR1 Pathway in Neuropathic Pain: An Update
by: Rita Silva, et al.
Published: (2021-07-01)

Spinal Cord Stimulation for Neuropathic Pain: Current Trends and Future Applications
by: Ivano Dones, et al.
Published: (2018-07-01)

Electroacupuncture Treatment Attenuates Paclitaxel-Induced Neuropathic Pain in Rats via Inhibiting Spinal Glia and the TLR4/NF-κB Pathway
by: Zhao YX, et al.
Published: (2020-01-01)

Electroacupuncture Restores Locomotor Functions After Mouse Spinal Cord Injury in Correlation With Reduction of PTEN and p53 Expression
by: Zhe Wei, et al.
Published: (2018-11-01)

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model
by: Yongda Liu, et al.
Published: (2020-02-01)

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain
by: Chaofan Wan, et al.
Published: (2021-01-01)

New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain
by: Tomohiro Yamashita, et al.
Published: (2021-02-01)

Simultaneous intrathecal injection of muscimol and endomorphin‐1 alleviates neuropathic pain in rat model of spinal cord injury
by: Marjan Hosseini, et al.
Published: (2020-05-01)

Electroacupuncture suppresses glucose metabolism and GLUT-3 expression in medial prefrontal cortical in rats with neuropathic pain
by: Menghong Jiang, et al.
Published: (2021-08-01)

An unusual presentation of neuropathic pain following cervical spinal cord injury: a case report
by: Min Cheol Chang, et al.
Published: (2020-02-01)

Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord
by: Ju-Young Oh, et al.
Published: (2020-01-01)

Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study
by: Elena Revuelta‐López, et al.
Published: (2020-04-01)

Functional Integrity of Somatosensory Pathways in the Neuropathic Pain Conditions After Spinal Cord Injury
by: Cruz-Almeida, Yenisel
Published: (2011)

Comparison of effect of electroacupuncture and nefopam for prevention of postanesthetic shivering in patients undergoing urologic operation under spinal anesthesia
by: Jun-Ho Hong, et al.
Published: (2016-12-01)

Electroacupuncture-Related Metabolic Brain Connectivity in Neuropathic Pain due to Brachial Plexus Avulsion Injury in Rats
by: Ao-Lin Hou, et al.
Published: (2020-06-01)

The microglial activation profile and associated factors after experimental spinal cord injury in rats
by: Zhou Y, et al.
Published: (2018-09-01)

Management of Chronic and Neuropathic Pain with 10 kHz Spinal Cord Stimulation Technology: Summary of Findings from Preclinical and Clinical Studies
by: Vinicius Tieppo Francio, et al.
Published: (2021-06-01)

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury
by: Arash Sarveazad, et al.
Published: (2019-06-01)

Spinal Inhibition of GABAB Receptors by the Extracellular Matrix Protein Fibulin-2 in Neuropathic Rats
by: Marie-Amélie Papon, et al.
Published: (2020-07-01)

Relationship of Inflammatory Cytokines From M1-Type Microglia/Macrophages at the Injured Site and Lumbar Enlargement With Neuropathic Pain After Spinal Cord Injury in the CCL21 Knockout (plt) Mouse
by: Kazuya Honjoh, et al.
Published: (2019-11-01)

Electroacupuncture Alleviates Diabetic Peripheral Neuropathy by Regulating Glycolipid-Related GLO/AGEs/RAGE Axis
by: Xuan Wang, et al.
Published: (2021-07-01)

The relationship of test anxiety to serum Beta-endorphin /
by: Molinaro, Jane Anne
Published: (1986)