Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.

Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. Insulin2 mutant (Ins2+/-) Akita is a mouse model of T1DM, which manifests cardiac dysfunction. However, molecular...

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Bibliographic Details
Main Authors: Varun Kesherwani, Hamid R Shahshahan, Paras K Mishra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5570368?pdf=render

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