S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity.

S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity.

The Schistosoma mansoni SmKI-1 protein is composed of two domains: a Kunitz-type serine protease inhibitor motif (KD) and a C-terminus domain with no similarity outside the genera. Our previous work has demonstrated that KD plays an essential role in neutrophil elastase (NE) binding blockage, in neu...

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Bibliographic Details
Main Authors: Fábio Mambelli, Bruno P O Santos, Suellen B Morais, Enrico G T Gimenez, Duana C Dos S Astoni, Amanda D Braga, Rafaela S Ferreira, Flávio A Amaral, Mariana T Q de Magalhães, Sergio C Oliveira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009007

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