CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION

CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION

Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and th...

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Main Authors: S. Y. Nikulina, V. A. Schulman, O. O. Kuznetsova, N. V. Aksjutina, P. A. Shesternja, A. A. Chernova, V. N. Maksimov, I. V. Kulikov, S. N. Ustinov, Y. L. Kazarinova, A. G. Romashchenko, M. I. Voevoda
Format: Article
Language:English
Published: Stolichnaya Izdatelskaya Kompaniya 2016-01-01
Series:Racionalʹnaâ Farmakoterapiâ v Kardiologii
Subjects:
idiopathic atrial fibrillation
inheritance
gene of β1-adrenoreceptors
Online Access:https://www.rpcardio.com/jour/article/view/1074
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author S. Y. Nikulina
V. A. Schulman
O. O. Kuznetsova
N. V. Aksjutina
P. A. Shesternja
A. A. Chernova
V. N. Maksimov
I. V. Kulikov
S. N. Ustinov
Y. L. Kazarinova
A. G. Romashchenko
M. I. Voevoda
spellingShingle S. Y. Nikulina
V. A. Schulman
O. O. Kuznetsova
N. V. Aksjutina
P. A. Shesternja
A. A. Chernova
V. N. Maksimov
I. V. Kulikov
S. N. Ustinov
Y. L. Kazarinova
A. G. Romashchenko
M. I. Voevoda
CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
Racionalʹnaâ Farmakoterapiâ v Kardiologii
idiopathic atrial fibrillation
inheritance
gene of β1-adrenoreceptors
author_facet S. Y. Nikulina
V. A. Schulman
O. O. Kuznetsova
N. V. Aksjutina
P. A. Shesternja
A. A. Chernova
V. N. Maksimov
I. V. Kulikov
S. N. Ustinov
Y. L. Kazarinova
A. G. Romashchenko
M. I. Voevoda
author_sort S. Y. Nikulina
title CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
title_short CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
title_full CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
title_fullStr CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
title_full_unstemmed CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION
title_sort clinical and genetic peculiarities of atrial fibrillation
publisher Stolichnaya Izdatelskaya Kompaniya
series Racionalʹnaâ Farmakoterapiâ v Kardiologii
issn 1819-6446
2225-3653
publishDate 2016-01-01
description Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.
topic idiopathic atrial fibrillation
inheritance
gene of β1-adrenoreceptors
url https://www.rpcardio.com/jour/article/view/1074
work_keys_str_mv AT synikulina clinicalandgeneticpeculiaritiesofatrialfibrillation
AT vaschulman clinicalandgeneticpeculiaritiesofatrialfibrillation
AT ookuznetsova clinicalandgeneticpeculiaritiesofatrialfibrillation
AT nvaksjutina clinicalandgeneticpeculiaritiesofatrialfibrillation
AT pashesternja clinicalandgeneticpeculiaritiesofatrialfibrillation
AT aachernova clinicalandgeneticpeculiaritiesofatrialfibrillation
AT vnmaksimov clinicalandgeneticpeculiaritiesofatrialfibrillation
AT ivkulikov clinicalandgeneticpeculiaritiesofatrialfibrillation
AT snustinov clinicalandgeneticpeculiaritiesofatrialfibrillation
AT ylkazarinova clinicalandgeneticpeculiaritiesofatrialfibrillation
AT agromashchenko clinicalandgeneticpeculiaritiesofatrialfibrillation
AT mivoevoda clinicalandgeneticpeculiaritiesofatrialfibrillation
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spelling doaj-fc37caed26a849e68059ecfc517af7a72021-09-03T13:15:23ZengStolichnaya Izdatelskaya KompaniyaRacionalʹnaâ Farmakoterapiâ v Kardiologii1819-64462225-36532016-01-0142131810.20996/1819-6446-2008-4-2-13-181073CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATIONS. Y. Nikulina0V. A. Schulman1O. O. Kuznetsova2N. V. Aksjutina3P. A. Shesternja4A. A. Chernova5V. N. Maksimov6I. V. Kulikov7S. N. Ustinov8Y. L. Kazarinova9A. G. Romashchenko10M. I. Voevoda11Krasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskAim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.https://www.rpcardio.com/jour/article/view/1074idiopathic atrial fibrillationinheritancegene of β1-adrenoreceptors

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