CLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATION

• Main Authors: S. Y. Nikulina, V. A. Schulman, O. O. Kuznetsova, N. V. Aksjutina, P. A. Shesternja, A. A. Chernova, V. N. Maksimov, I. V. Kulikov, S. N. Ustinov, Y. L. Kazarinova, A. G. Romashchenko, M. I. Voevoda
• Format: Article
• Language: English
• Published: Stolichnaya Izdatelskaya Kompaniya 2016-01-01
• Series: Racionalʹnaâ Farmakoterapiâ v Kardiologii
• Subjects: idiopathic atrial fibrillation; inheritance; gene of β1-adrenoreceptors
• Online Access: https://www.rpcardio.com/jour/article/view/1074
• ISSN: 1819-6446; 2225-3653

Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.